UMB-32

UMB-32 is an inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L. UMB-32 binds BRD4 with a Kd of 550 nM and the EC₅₀ is 724 nM in BRD4-dependent lines. UMB-32 binds to TAF1 and TAF1L with the Kd values of 560 nM and 1.3 μM, respectively.