p-nitro-Pifithrin-α

p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α. Pifithrin-α is an inhibitor of p53 that blocks p53-dependent apoptosis. p-nitro-Pifithrin-α blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons more potently than pifithrin-α. It suppresses the expression of TGF-β1 in human proximal tubular cells (HK-2 cells) at a concentration of 10 μM. It reduces hepatic triglyceride accumulation and lipotoxicity in mice fed a high fat diet.