CAY10685

CAY10685 is an active clickable analog of the lysine acetyltransferase inhibitor 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole (CPTH2 hydrochloride). The alkyne moiety reacts with an azide group upon copper exposure which tags the “clickable” molecules in cells. N-acetyltransferase 10 (NAT10) is a specific target of CAY10685. The inhibitor is used to study NAT10, it's role in nuclear architecture and for strategies to treat laminopathies and aging.