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BRD9539

BRD9539 is a specific inhibitor of euchromatin histone methyltransferase G9a (EHMT2). EHMT2 catalyzes the methylation of lysine 9 on histone H3. BRD9539 inhibits EHMT2 with an IC₅₀ of 6.3 μM. It also inhibits methyl transferase PRC2 with a similar IC₅₀. It is the methyl-ester analogue of BRD4770. It is more potent than BRD4770 in enzyme assays but does not show activity in cell-based assays, probably due to impaired cell permeability compared to that of BRD4770.

Product Specifications

Shipping Conditions

Gel Pack

Storage Conditions

-20ºC

Shelf Life

36 months

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