JGB1741
JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC₅₀ value of JGB1741 in a cell-free assay is 15 μM. The IC₅₀ for cell proliferation of three cancer cell lines, K562, HepG2 and MDA-MB 231 is 1 μM, 10 μM and 0.5 μM, respectively. JGB1741 causes cytochrome c release, modulation in Bax/Bcl2 ratio and cleavage of PARP.
Product Specifications
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months
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