MK-886

MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes (IC₅₀ of 2.5 nM). MK-886 also inhibits cyclooxygenase-1 (COX-1) activity and suppresses platelet aggregation.