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SAR-125844

SAR-125844 is a potent, selective, reversible and ATP-competitive c-MET inhibitor, with an IC₅₀ of 4.2 nM. Displays inhibition of MET autophosphorylation in cell-based assays. Upon intravenous administration, SAR-125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways.This may result in cell growth inhibition in tumors that overexpress c-Met.

Product Specifications

Shipping Conditions

Gel Pack

Storage Conditions

-20ºC

Shelf Life

36 months

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