Question 1

What is the catalog number for PF-04449913?

Accepted Answer

The catalog number for PF-04449913 is B2467-5.

Question 2

Is PF-04449913 in stock?

Accepted Answer

PF-04449913 is currently made to order / not held in immediate stock. Contact us for lead time.

Question 3

What is PF-04449913 used for?

Accepted Answer

PF-04449913 is a potent and orally bioavailable smoothened (SMO) inhibitor. PF-04449913 binds to human SMO with an IC₅₀ of 4 nM. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model.

Question 4

What is the recommended positive control for this assay?

Accepted Answer

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Question 5

How should this product be stored?

Accepted Answer

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Question 6

Is this product animal-origin-free?

Accepted Answer

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

PF-04449913

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