Question 1

What is the catalog number for PF-04449913?

Accepted Answer

The catalog number for PF-04449913 is B2467-1.

Question 2

Is PF-04449913 in stock?

Accepted Answer

PF-04449913 is currently made to order / not held in immediate stock. Contact us for lead time.

Question 3

What is PF-04449913 used for?

Accepted Answer

PF-04449913 is a potent and orally bioavailable smoothened (SMO) inhibitor. PF-04449913 binds to human SMO with an IC₅₀ of 4 nM. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model.

Question 4

Can this product be used for diagnostic or therapeutic purposes?

Accepted Answer

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

Question 5

What is the shelf life of this product?

Accepted Answer

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

Question 6

What expression system was used for this recombinant protein?

Accepted Answer

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

PF-04449913

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