TLR1
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1].
Product Specifications
CAS Number
566914-00-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MyD88
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr1.html
Concentration
33 mM * 100 μL in Ethanol
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N1CCCC1)=O)C(C)C)CCC2=CC=CC=C2
Molecular Formula
C18H26N2O2
Molecular Weight
302.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100 (13) :7971-6.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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