TLR1

TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1].

Product Specifications

CAS Number

[566914-00-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MyD88

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tlr1.html

Concentration

33 mM * 100 μL in Ethanol

Purity

99.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N1CCCC1)=O)C(C)C)CCC2=CC=CC=C2

Molecular Formula

C18H26N2O2

Molecular Weight

302.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100 (13) :7971-6.