PROTAC ERα Degrader-8
PROTAC ERα Degrader-8 (compound ii-56) is a potent PROTAC degrader of Erα, with DC50 of 0.000006 μM in MCF7 cells[1].
Product Specifications
CAS Number
3025533-68-7
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-erα-degrader-8.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C2[C@H](C3=CC=C(N([C@@]4([H])C5)[C@](CC4)([H])CC5CN6CCN(C7=CC=C8C(CN([C@@H](CCC9=O)C(N9)=O)C8=O)=C7)CC6)C=C3)[C@H](C%10=CC=CC=C%10)CCC2=C1
Molecular Formula
C47H51N5O4
Molecular Weight
749.94
References & Citations
[1]Relay Therapeutics, Inc. Preparation of bifunctional compounds as estrogen receptor alpha degraders and use thereof. World Intellectual Property Organization, WO2024006781 A1 2024-01-04
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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