JNK2 Rabbit rabbit pAb

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the Cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternative

Product Specifications

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternative

UniProt

P45984

Swiss Prot

P45984

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein of JNK2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF

Concentration

1 mg/ml

Dilution

WB 1:500-2000, IHC-p 1:50-300

Molecular Weight

46,54kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

46,54kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus . Colocalizes with POU5F1 in the nucleus. .

Other Product Names

Mitogen-activated protein kinase 9 (MAP kinase 9; MAPK 9; EC 2.7.11.24; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2)