BMS-3
BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
Product Specifications
CAS Number
[1338247-30-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
LIM Kinase (LIMK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BMS-3.html
Purity
99.89
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1CC1)NC2=NC=C(C3=CC(C(F)F)=NN3C4=C(Cl)C=CC=C4Cl)S2
Molecular Formula
C17H12Cl2F2N4OS
Molecular Weight
429.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7 (11) :3490-8.|[2]Romarowski A, et al. PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosis. Dev Biol. 2015 Sep 15;405 (2) :237-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LIMK1; LIMK2
Available Sizes
Curated Selection
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