(R) -NX-2127

(R) -NX-2127 ((R) -Compound 28) is an isomer of the BTK PROTAC degrader NX-2127 (HY-153220) [1]. (Pink: BTK ligand 10 (HY-168302) ; Black: (S) -4- (1- (Pyrrolidin-3-ylmethyl) piperidin-4-yl) aniline (HY-168303) ; Blue: Thalidomide 5-fluoride (HY-W087383) .

Product Specifications

CAS Number

[3024312-52-2]

UNSPSC

12352005

Target

Btk; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-nx-2127.html

Purity

98.93

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC(N3C[C@@H](CN4CCC(C5=CC=C(C=C5)NC6=C(N=CC(N7CCCCC7)=N6)C(N)=O)CC4)CC3)=CC=C2C(N1C8C(NC(CC8)=O)=O)=O

Molecular Formula

C39H45N9O5

Molecular Weight

719.83

References & Citations

[1]Robbins DW, et al. Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J Med Chem. 2024 Feb 22;67 (4) :2321-2336.