KDM5-C49 (hydrochloride)

KDM5-C49 (KDOAM-20) hydrochloride is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 hydrochloride can be used for the research of cancer[1].

Product Specifications

CAS Number

[3026728-26-4]

Product Name Alternative

KDOAM-20 (hydrochloride)

UNSPSC

12352005

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kdm5-c49-hydrochloride.html

Purity

98.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)O.[H]Cl

Molecular Formula

C15H25ClN4O3

Molecular Weight

344.84

References & Citations

[1]Horton JR, et, al. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol. 2016 Jul 21;23 (7) :769-781.|[2]Song YQ, et al. The role and prospect of lysine-specific demethylases in cancer chemoresistance. Med Res Rev. 2023 Apr 3.