D-Mannose

D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation[1][2][3].

Product Specifications

CAS Number

[3458-28-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others; Cancer

Assay Protocol

https://www.medchemexpress.com/D-Mannose.html

Purity

98.5

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O

Molecular Formula

C6H12O6

Molecular Weight

180.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Torretta S, et al. D-mannose suppresses macrophage IL-1β production. Nat Commun. 2020 Dec 11;11 (1) :6343.|[2]Zhang D, et al. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23 (9) :1036-1045.|[3]Liu H, et al. D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects. Ther Adv Chronic Dis. 2020 Apr 17;11:2040622320912661.