D-Mannose
D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation[1][2][3].
Product Specifications
CAS Number
[3458-28-4]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/D-Mannose.html
Purity
98.5
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O
Molecular Formula
C6H12O6
Molecular Weight
180.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Torretta S, et al. D-mannose suppresses macrophage IL-1β production. Nat Commun. 2020 Dec 11;11 (1) :6343.|[2]Zhang D, et al. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23 (9) :1036-1045.|[3]Liu H, et al. D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects. Ther Adv Chronic Dis. 2020 Apr 17;11:2040622320912661.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
Phase 4
Isoform
Human Endogenous Metabolite
Available Sizes
Curated Selection
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