PD 4'-oxyacetic acid
PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development[1].
Product Specifications
CAS Number
[2633633-12-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pd-4-oxyacetic-acid.html
Purity
99.69
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)COC1=CC=C(N(C(N2)=O)CCC2=O)C=C1
Molecular Formula
C12H12N2O5
Molecular Weight
264.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Jarusiewicz JA, et al. Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design. ACS Med Chem Lett. 2023;14 (2) :141-145. Published 2023 Jan 4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
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