XPC-5462
Product Specifications
UNSPSC Description
XPC-5462 is a NaV1.6 and NaV1.2 inhibitor with the IC50s of 10.9 nM and 10.3 nM, respectively. XPC-5462 suppresses epileptiform activity in an ex vivo brain slice seizure model[1].
Target Antigen
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/xpc-5462.html
Solubility
10 mM in DMSO
Smiles
O=S(NC1=CSC=N1)(C2=C(C=C(C=C2F)NCC3=C(C(F)=CC=C3F)CN4CCC4)F)=O
Molecular Weight
486.51
References & Citations
[1]Goodchild SJ,et al. Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo. ACS Chem Neurosci. 2024 Feb 15.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157786/XPC-5462-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157786/
Clinical Information
No Development Reported
CAS Number
2230145-14-7
Available Sizes
Curated Selection
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