Biotinidase (Human, Highly Pure)

<strong>Biotinidase (Human, Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2010464_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 58.2 kDa_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure (&gt;95%) biotinidase expressed in HEK293 cells and highly active in hydrolyzing biocytin into lysine and biotin._x000D_ <strong>Storage:</strong> −20°C_x000D_ <strong>Keywords:</strong> BTD Protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Canda E, Kalkan Uçar S, Çoker M. Biotinidase Deficiency: Prevalence, Impact_x000D_ And Management Strategies. Pediatric Health Med Ther. 2020 May 4;11:127-133._x000D_ _x000D_ 2: Wolf B. Biotinidase deficiency should be considered in individuals exhibiting_x000D_ myelopathy with or without and vision loss. Mol Genet Metab. 2015_x000D_ Nov;116(3):113-8._x000D_ _x000D_ 3: Santoro JD, Paulsen KC. Biotinidase Deficiency as a Mimic of Neuromyelitis_x000D_ Optica Spectrum Disorder in Childhood. JAMA Neurol. 2020 Oct 5;78(1):118–20._x000D_ _x000D_ 4: Shah S, Khan N, Lakshmanan R, Lewis B, Nagarajan L. Biotini_dase deficiency_x000D_ presenting as Neuromyelitis Optica Spectrum Disorder. Brain Dev. 2020_x000D_ Nov;42(10):762-766._x000D_ _x000D_ 5: Wolf B. Biotini_dase deficiency: "if you have to have an inherited metabolic_x000D_ disease, this is the one to have". Genet Med. 2012 Jun;14(6):565-75._x000D_ _x000D_ 6: Yang Y, Yang JY, Chen XJ. Biotini_dase deficiency characterized by skin and_x000D_ hair findings. Clin Dermatol. 2020 Jul-Aug;38(4):477-483._x000D_ _x000D_ 7: Bilge N, Yevgi R. Biotini_dase deficiency in differential diagnosis of_x000D_ neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020_x000D_ Sep;44:102280._x000D_ _x000D_ 8: Hymes J, Wolf B. Human biotinidase isn't just for recycling biotin. J Nutr._x000D_ 1999 Feb;129(2S Suppl):485S-489S._x000D_ _x000D_ 9: Funghini S, Tonin R, Malvagia S, Caciotti A, Donati MA, Morrone A, la Marca_x000D_ G. High frequency of biotinidase deficiency in Italian population identified by_x000D_ newborn screening. Mol Genet Metab Rep. 2020 Dec 5;25:100689._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/26577040/">10: Küry S, Ramaekers V, Bézieau S, Wolf B. Clinical utility gene card for:_x000D_ Biotinidase deficiency-update 2015. Eur J Hum Genet. 2016 Jul;24(7). </a>_x000D_ _x000D_ <strong>Products Related to Biotinidase (Human, Highly Pure) </strong> <a href="https://moleculardepot.com/product-category/Enzymes/">: Enzymes</a>