2-Hydroxybenzimidazole

2-Hydroxybenzimidazole is an inactive compound targeting CYP1A1 and is mainly used as a control compound in the structure-activity relationship study of benzimidazole derivatives. 2-Hydroxybenzimidazole does not have the ability to induce CYP1A1 expression like its thiol or amino substituted derivatives[1].

Product Specifications

CAS Number

[615-16-7]

UNSPSC

12352200

Hazard Statement

H302

Target

Cytochrome P450

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-hydroxybenzimidazole.html

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1NC2=CC=CC=C2N1

Molecular Formula

C7H6N2O

Molecular Weight

134.14

Precautions

H302

References & Citations

[1]Backlund M, et al. Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. Eur J Biochem. 1999 Apr;261 (1) :66-71.