2-Hydroxybenzimidazole
2-Hydroxybenzimidazole is an inactive compound targeting CYP1A1 and is mainly used as a control compound in the structure-activity relationship study of benzimidazole derivatives. 2-Hydroxybenzimidazole does not have the ability to induce CYP1A1 expression like its thiol or amino substituted derivatives[1].
Product Specifications
CAS Number
615-16-7
UNSPSC
12352200
Hazard Statement
H302
Target
Cytochrome P450
Type
Biochemical Assay Reagents
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-hydroxybenzimidazole.html
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=CC=C2N1
Molecular Formula
C7H6N2O
Molecular Weight
134.14
Precautions
H302
References & Citations
[1]Backlund M, et al. Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. Eur J Biochem. 1999 Apr;261 (1) :66-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
CYP1
Available Sizes
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