E6AP-mimicking peptide
Product Specifications
UNSPSC Description
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture[1].
Target Antigen
HPV
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/e6ap-mimicking-peptide.html
Smiles
C=C(NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@@H](NC(CC2C3=C(C=CC=C3)C4=C2C=CC=C4)=O)[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)[C@@H](C)O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCNC(C5=C6C=C7C=CC=CC7=CC6=CC=C5)=O)C(N)=O)=O)=O)=O)=O)=O
Molecular Weight
2630.09
References & Citations
[1]Xiyun Ye, et al. Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6. Chem Sci. 2023 Oct 25;14(44):12484-12497.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10428/E6AP-mimicking-peptide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10428/
Clinical Information
No Development Reported
Curated Selection
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