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E6AP-mimicking peptide

E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture[1].

Product Specifications

UNSPSC

12352209

Target

HPV

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/e6ap-mimicking-peptide.html

Smiles

C=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCNC(C1=C2C=C3C=CC=CC3=CC2=CC=C1)=O)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H]4CCCN4C([C@H]([C@@H](C)CC)NC(CC5C(C=CC=C6)=C6C7=C5C=CC=C7)=O)=O)=O)=O)CO)=O)C)=O)CCC(O)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O

Molecular Formula

C128H193N31O29

Molecular Weight

2630.09

References & Citations

[1]Xiyun Ye, et al. Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6. Chem Sci. 2023 Oct 25;14 (44) :12484-12497.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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