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Sazetidine A (dihydrochloride)

Sazetidine A dihydrochloride is a potent ligand for the α4β2 nAChR, with high binding affinity and selectivity for this subtype. Sazetidine A dihydrochloride exhibits favorable pharmacological properties and may contribute to research targeting nicotinic receptor-related diseases. Sazetidine A dihydrochloride has been mentioned in studies investigating the binding affinity of various analogs, highlighting its importance in understanding the nAChR ligand subtype selectivity[1].

Product Specifications

CAS Number

2455450-63-0

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sazetidine-a-dihydrochloride.html

Smiles

OCCCCC#CC1=CC(OC[C@H]2NCC2)=CN=C1.Cl.Cl

Molecular Formula

C15H22Cl2N2O2

Molecular Weight

333.25

References & Citations

[1]Liu Y, et al. Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A. Bioorg Med Chem Lett. 2014 Jul 1;24 (13) :2954-6.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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