UPF-648
UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition) ; ineffective at blocking KAT activity.
Product Specifications
CAS Number
213400-34-1
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/UPF-648.html
Concentration
10mM
Purity
99.75
Solubility
10 mM in DMSO|Ethanol : ≥ 50 mg/mL
Smiles
O=C([C@@H]1[C@@H](C(C2=CC=C(Cl)C(Cl)=C2)=O)C1)O
Molecular Formula
C11H8Cl2O3
Molecular Weight
259.09
References & Citations
[1]Amori L, et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J Neurochem. 2009 Apr;109 (2) :316-25.|[2]Ceresoli-Borroni G, et al. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J Neurosci Res. 2007 Mar;85 (4) :845-54.|[3]Amaral M, et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496 (7445) :382-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
ABC-X0418C 1 Vial
XpressTM Mouse GPC3 Over-expressing Cell Line (293T)
Sign In for Pricing
View Details 
K0117802 1.0 µg DNA
ARHGEF5L sgRNA CRISPR Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
TA805898 100 µL
Factor I (CFI) Mouse Monoclonal Antibody [Clone ID: OTI4H9]
Sign In for Pricing
View Details