UPF-648

UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition) ; ineffective at blocking KAT activity.

Product Specifications

CAS Number

[213400-34-1]

UNSPSC

12352005

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/UPF-648.html

Concentration

10mM

Purity

99.75

Solubility

10 mM in DMSO|Ethanol : ≥ 50 mg/mL

Smiles

O=C([C@@H]1[C@@H](C(C2=CC=C(Cl)C(Cl)=C2)=O)C1)O

Molecular Formula

C11H8Cl2O3

Molecular Weight

259.09

References & Citations

[1]Amori L, et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J Neurochem. 2009 Apr;109 (2) :316-25.|[2]Ceresoli-Borroni G, et al. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J Neurosci Res. 2007 Mar;85 (4) :845-54.|[3]Amaral M, et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496 (7445) :382-5.