SML-10-70-1
SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC50 of 26.6-47.6 μM[1].
Product Specifications
CAS Number
1536470-98-0
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sml-10-70-1.html
Smiles
O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OCCNC(CCl)=O)(N[C@@H](C)C(OCC(CCC)CCC)=O)=O)(O)=O)O3)=C2N=C(N)N1
Molecular Formula
C25H42ClN7O13P2
Molecular Weight
746.04
References & Citations
[1]Lim SM, et al., Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl. 2014 Jan 3;53 (1) :199-204.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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