A-61603 (free base)
A-61603 free base is a potent adrenergic receptor agonist. A-61603 free base reduces carotid artery conductance in anesthetized pigs mediated by α1 and α2 adrenergic receptors (pEC50=7.25) . A-61603 free base can be used as a probe to study adrenergic function[1][2].
Product Specifications
CAS Number
750531-54-5
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-61603-free-base.html
Smiles
CS(=O)(NC1=C2CCCC(C2=CC=C1O)C3=NCCN3)=O
Molecular Formula
C14H19N3O3S
Molecular Weight
309.38
References & Citations
[1]Knepper S M, et al. A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274 (1) : 97-103.|[2]Mehrotra S, et al. A61603‐Induced Contractions of the Porcine Meningeal Artery Are Mediated by α1‐and α2‐Adrenoceptors[J]. Basic & clinical pharmacology & toxicology, 2007, 100 (4) : 279-285.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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