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A-61603 (free base)

A-61603 free base is a potent adrenergic receptor agonist. A-61603 free base reduces carotid artery conductance in anesthetized pigs mediated by α1 and α2 adrenergic receptors (pEC50=7.25) . A-61603 free base can be used as a probe to study adrenergic function[1][2].

Product Specifications

CAS Number

750531-54-5

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-61603-free-base.html

Smiles

CS(=O)(NC1=C2CCCC(C2=CC=C1O)C3=NCCN3)=O

Molecular Formula

C14H19N3O3S

Molecular Weight

309.38

References & Citations

[1]Knepper S M, et al. A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274 (1) : 97-103.|[2]Mehrotra S, et al. A61603‐Induced Contractions of the Porcine Meningeal Artery Are Mediated by α1‐and α2‐Adrenoceptors[J]. Basic & clinical pharmacology & toxicology, 2007, 100 (4) : 279-285.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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