GSDMD antibody
Product Specifications
Background
GSDMD is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. GSDMD has been suggested to act as a tumor suppressor. Recently, GSDMD is identified as a new component of inflammasomes, and it is an executor of pyroptosis and required for interleukin-1β secretion. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Synonyms
Gasdermin-D|Gasdermin domain-containing protein 1|Gasdermin-D, C-terminal (GSDMD-CT, hGSDMD-CTD) |Gasdermin-D, p13|Gasdermin-D, 13 kDa (13 kDa GSDMD) |Gasdermin-D, p40|GSDMD|DFNA5L|GSDMDC1
Gene ID
79792
UniProt
P57764
Host
Mouse
Reactivity
Human
Immunogen
Gasdermin D
Target
GSDMD
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, IF
Field of Research
Developmental biology
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:5000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
47-53 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
10D7
Tested Applications
ELISA, WB, IF
Immunogen Sequence
276-484aa
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