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Topoisomerase I inhibitor 16

Selected Variant

HY-161385

Size: 1 Each

Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM[1].

Product Specifications

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-i-inhibitor-16.html

Solubility

10 mM in DMSO

Smiles

OC1=CC2=C(C=C1)C3=C(C(N=CC4=C5C=C(OC)C(O)=C4)=C5N3CCCN6CCOCC6)C=C2

Molecular Formula

C27H27N3O4

Molecular Weight

457.52

References & Citations

[1]Sakai K, et al., Design, synthesis, and biological evaluation of novel benzo[6,7]indolo[3,4-c]isoquinolines as anticancer agents with topoisomerase I inhibition. Bioorg Med Chem Lett. 2024 Mar 20:129710.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Topo I

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