Topoisomerase I inhibitor 16
Selected Variant
HY-161385
Size: 1 Each
Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM[1].
Product Specifications
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-i-inhibitor-16.html
Solubility
10 mM in DMSO
Smiles
OC1=CC2=C(C=C1)C3=C(C(N=CC4=C5C=C(OC)C(O)=C4)=C5N3CCCN6CCOCC6)C=C2
Molecular Formula
C27H27N3O4
Molecular Weight
457.52
References & Citations
[1]Sakai K, et al., Design, synthesis, and biological evaluation of novel benzo[6,7]indolo[3,4-c]isoquinolines as anticancer agents with topoisomerase I inhibition. Bioorg Med Chem Lett. 2024 Mar 20:129710.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
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