Mofegiline (hydrochloride)

Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of MAO-B, with marked selectivity on the MAO-B over MAO-A with IC50s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride is also an inhibitor of semicarbazide-sensitive amine oxidase (SSAO) [1][2][3].

Product Specifications

CAS Number

[120635-25-8]

Product Name Alternative

MDL72974A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Mofegiline-hydrochloride.html

Purity

99.57

Solubility

DMSO : 110 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

FC1=CC=C(CC/C(CN)=C(F)/[H])C=C1.[H]Cl

Molecular Formula

C11H14ClF2N

Molecular Weight

233.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Zreika M, et al. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease. J Neural Transm Park Dis Dement Sect. 1989;1 (4) :243-54.|[2]Yu PH, et al. Inhibition of a type B monoamine oxidase inhibitor, (E) -2- (4-fluorophenethyl) -3-fluoroallylamine (MDL-72974A), on semicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species. Biochem Pharmacol. 1992 Jan 22;43 (2) :307-12.|[3]Dow J, et al. Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans. Drug Metab Dispos. 1994 Sep-Oct;22 (5) :738-49.|[4]Fang J, et al. Effect of L-deprenyl, its structural analogues and some monoamine oxidase inhibitors on dopamine uptake. Neuropharmacology. 1994 Jun;33 (6) :763-8.