Human Leptin (Recombinant, Highly Pure)

<strong>Human Leptin (Recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2010270_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 50 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure recombinant leptin, a protein involved in the monitoring of the size of the adipose tissue. Leptin levels correlate with fat mass._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuLeptin; Obesity protein; OB_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Farr OM, Gavrieli A, Mantzoros CS. Leptin applications in 2015: what have we_x000D_ learned about leptin and obesity? Curr Opin Endocrinol Diabetes Obes. 2015_x000D_ Oct;22(5):353-9._x000D_ _x000D_ 2: Flier JS, Maratos-Flier E. Leptin's Physiologic Role: Does the Emperor of_x000D_ Energy Balance Have No Clothes? Cell Metab. 2017 Jul 5;26(1):24-26._x000D_ _x000D_ 3: Van Doorn C, Macht VA, Grillo CA, Reagan LP. Leptin resistance and_x000D_ hippocampal behavioral deficits. Physiol Behav. 2017 Jul 1;176:207-213._x000D_ _x000D_ 4: Guzmán A, Hernández-Coronado CG, Rosales-Torres AM, Hernández-Medrano JH._x000D_ Leptin regulates neuropeptides associated with food intake and GnRH secretion._x000D_ Ann Endocrinol (Paris). 2019 Feb;80(1):38-46._x000D_ _x000D_ 5: McGregor G, Harvey J. Food for thought: Leptin regulation of hippocampal_x000D_ function and its role in Alzheimer's disease. Neuropharmacology. 2018 Jul_x000D_ 1;136(Pt B):298-306._x000D_ _x000D_ 6: Procaccini C, La Rocca C, Carbone F, De Rosa V, Galgani M, Matarese G. Leptin_x000D_ as immune mediator: Interaction between neuroendocrine and immune system. Dev_x000D_ Comp Immunol. 2017 Jan;66:120-129._x000D_ _x000D_ 7: Szczesna M, Zieba DA. Phenomenon of leptin resistance in seasonal animals:_x000D_ the failure of leptin action in the brain. Domest Anim Endocrinol. 2015_x000D_ Jul;52:60-70._x000D_ _x000D_ 8: Kasacka I, Piotrowska Ż, Niezgoda M, Łebkowski W. Differences in leptin_x000D_ biosynthesis in the stomach and in serum leptin level between men and women. J_x000D_ Gastroenterol Hepatol. 2019 Nov;34(11):1922-1928._x000D_ _x000D_ 9: Zabeau L, Wauman J, Dam J, Van Lint S, Burg E, De Geest J, Rogge E, Silva A,_x000D_ Jockers R, Tavernier J. A novel leptin receptor antagonist uncouples leptin's_x000D_ metabolic and immune functions. Cell Mol Life Sci. 2019 Mar;76(6):1201-1214._x000D_ _x000D_ 10: de Git KCG, den Outer JA, Wolterink-Donselaar IG, Luijendijk MCM, Schéle E,_x000D_ Dickson SL, Adan RAH. Rats that are predisposed to excessive obesity show_x000D_ reduced (leptin-induced) thermoregulation even in the preobese state. Physiol_x000D_ Rep. 2019 Jul;7(14):e14102._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/29944392/">11: Deem JD, Muta K, Ogimoto K, Nelson JT, Velasco KR, Kaiyala KJ, Morton GJ._x000D_ Leptin regulation of core body temperature involves mechanisms independent of_x000D_ the thyroid axis. Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E552-E564.</a>_x000D_ _x000D_ <strong>Products Related to Human Leptin (Recombinant) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>