eEF2K degrader-1
Product Specifications
UNSPSC Description
eEF2K degrader-1c (compound 36) is a type of eEF2K degrader. eEF2K degrader-1 can inhibit the viability, proliferation, and migration of the MDA-MB-231 and HCC1806 cell lines, with an IC50 value of 43.71 nM for MDA-MB-231. eEF2K degrader-1 shows tumor-suppressing effects in mouse models with MDA-MB-231 cell xenografts[1].
Target Antigen
CaMK
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eef2k-degrader-1.html
Smiles
CC1=C(C=CC(N2C(N(C(C(C(N3CCCCC3)=O)=N2)=O)CC4=CC=CC=C4)=O)=C1)C
Molecular Weight
418.49
References & Citations
[1]Zhao X, et al. Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2H,4H)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15837-15861.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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