GSK878

GSK878 is a highly potent, long-acting HIV-1 inhibitor with the EC50 of 39 pM[1].

Product Specifications

CAS Number

[2417048-11-2]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gsk878.html

Smiles

O=C1N(C2=CC=C(Cl)C3=C2N(C)N=C3NS(C)(=O)=O)C([C@@H](NC(CN4C(C(F)(F)[C@@]5([H])[C@]6([H])C5)=C6C(C(F)F)=N4)=O)CC7=CC(F)=CC(F)=C7)=NC8=C1C=CC(N9C[C@H](C)O[C@H](C)C9)=C8

Molecular Formula

C41H38ClF6N9O5S

Molecular Weight

918.31

References & Citations

[1]Gillis EP, et al. Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold. J Med Chem. 2023;66 (3) :1941-1954.