1-Pyrenebutyric acid

1-Pyrenebutyric acid is a fluorescence probe whose fluorescence lifetime depends on local oxygen and free radical concentrations. 1-Pyrenebutyric acid is used in fluorescence determination of DNA. 1-Pyrenebutyric acid can be used as a linker for biomolecules to form a self-assembled monolayer on grapheme. 1-Pyrenebutyric acid can also be used for the measurement of free radicals in solution and in living cells[1][2][3][4].

Product Specifications

CAS Number

[3443-45-6]

UNSPSC

12171500

Hazard Statement

H315, H319, H335

Target

Fluorescent Dye; Reactive Oxygen Species (ROS)

Type

Dye Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-pyrenebutyric-acid.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1=CC2=C3C(=C1)C=CC4=C(CCCC(=O)O)C=CC(=C43)C=C2

Molecular Formula

C20H16O2

Molecular Weight

288.35

Precautions

H315, H319, H335

References & Citations

[1]Wang L, et, al. Fluorescence determination of DNA with 1-pyrenebutyric acid nanoparticles coated with beta-cyclodextrin as a fluorescence probe. Spectrochim Acta A Mol Biomol Spectrosc. 2005 Apr;61 (6) :1201-5.|[2]Hinnemo M, et, al. On Monolayer Formation of Pyrenebutyric Acid on Graphene. Langmuir. 2017 Apr 18;33 (15) :3588-3593.|[3]Rharass, T., et al., (2006) . Variation of 1-pyrenebutyric acid fluorescence lifetime in single living cells treated with molecules increasing or decreasing reactive oxygen species levels. Analytical biochemistry, 357 (1), 1–8.|[4]Moné, Y., et al., (2011) . An example of molecular co-evolution: reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions. International journal for parasitology, 41 (7), 721–730.