BSJ-04-132
Product Specifications
UNSPSC Description
BSJ-04-132 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1].
Target Antigen
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bsj-04-132.html
Smiles
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCCCNC(COC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C
Molecular Weight
819.91
References & Citations
[1]Baishan Jiang, et al. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136252/BSJ-04-132-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136252/BSJ-04-132-SDS-MedChemExpress.pdf
CAS Number
2349356-39-2
Available Sizes
Curated Selection
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