Cyromazine

Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats[1][2][3][4][5].

Product Specifications

CAS Number

[66215-27-8]

Product Name Alternative

Cyromazin; CGA-72662

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Cyromazine.html

Purity

99.79

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

NC1=NC(N)=NC(NC2CC2)=N1

Molecular Formula

C6H10N6

Molecular Weight

166.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Levot GW, et al. Survival advantage of cyromazine-resistant sheep blowfly larvae on dicyclanil- and cyromazine-treated Merinos. Aust Vet J. 2014 Nov;92 (11) :421-6.|[2]Khalid MZ, et al. Cyromazine Effects the Reproduction of Drosophila by Decreasing the Number of Germ Cells in the Female Adult Ovary[J]. Insects. 2022 Apr 27;13 (5) :414.|[3]T. Heikal, A. Mossa, et al. Cyromazine and Chlorpyrifos Induced Renal Toxicity in Rats: The Ameliorated Effects of Green Tea Extract[J]. Journal of Environmental and Analytical Toxicology. 2012 June 9; 2 (5) : 1000146.|[4]Khalid MZ, et al. Cyromazine affects the ovarian germ cells of Drosophila via the ecdysone signaling pathway[J]. Front Physiol. 2022 Sep 29;13:992306.|[5]TAREK M.HEIKAL, et al. The ameliorating effects of green tea extract against cyromazine and chlorpyrifos induced liver toxicity in male rats[J]. Asian Journal of Pharmaceutical and Clinical Research. 2013 January; 6 (1) :47-55.