Anti-Mouse ICOS Antibody (7E.17G9)

Anti-Mouse ICOS Antibody (7E.17G9) is an anti-mouse ICOS IgG2b monoclonal antibody. Anti-Mouse ICOS Antibody (7E.17G9) can upregulate ICOS expression and enhance T cell function. Anti-Mouse ICOS Antibody (7E.17G9) can significantly inhibit the immune regulatory function of dendritic cells (DCs) . Anti-Mouse ICOS Antibody (7E.17G9) can eliminate transplant tolerance. Anti-Mouse ICOS Antibody (7E.17G9) can be used for researches on inflammation conditions, cancer and xenotransplantation such as nephritis and pancreatic cancer[1][2][3].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

CD28

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-icos-antibody-7e-17g9.html

Purity

Solubility

10 mM in DMSO

Smiles

[Anti-MouseICOSAntibody(7E.17G9)]

Molecular Weight

(150 kDa)

Precautions

H302, H315, H319, H335

References & Citations

[1]Borges TJ, et al. Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms. JCI Insight. 2021 Dec 22;6 (24) :e142909.|[2]Odobasic D, et al. Tolerogenic Dendritic Cells Attenuate Experimental Autoimmune Antimyeloperoxidase Glomerulonephritis. J Am Soc Nephrol. 2019 Nov;30 (11) :2140-2157.|[3]Wang W, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018 Nov 12;34 (5) :757-774.e7.