Azido-PEG2-CH2COOH
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[882518-90-3]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg2-ch2cooh.html
Purity
99.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)COCCOCCN=[N+]=[N-]
Molecular Formula
C6H11N3O4
Molecular Weight
189.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Yimin Qian, et al. Composés et procédés pour la dégradation ciblée de protéines contenant un bromodomaine. WO2017030814A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
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