ML252 (hydrochloride)
ML252 hydrochloride is a selective inhibitor of KCNQ2 (Kv7.2) channel with IC50s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 hydrochloride also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 hydrochloride shows highly brain penetrant[1][2].
Product Specifications
CAS Number
2309887-61-2
UNSPSC
12352005
Target
Cytochrome P450; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ml252-hydrochloride.html
Smiles
CC[C@@H](C1=CC=CC=C1)C(NC2=CC=CC=C2N3CCCC3)=O.Cl
Molecular Formula
C20H25ClN2O
Molecular Weight
344.88
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1; CYP2; CYP3; Voltage-gated potassium channel
Frequently Asked Questions
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