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ML252 (hydrochloride)

ML252 hydrochloride is a selective inhibitor of KCNQ2 (Kv7.2) channel with IC50s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 hydrochloride also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 hydrochloride shows highly brain penetrant[1][2].

Product Specifications

CAS Number

2309887-61-2

UNSPSC

12352005

Target

Cytochrome P450; Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml252-hydrochloride.html

Smiles

CC[C@@H](C1=CC=CC=C1)C(NC2=CC=CC=C2N3CCCC3)=O.Cl

Molecular Formula

C20H25ClN2O

Molecular Weight

344.88

References & Citations

[1]Yu H, et al. Identification of a novel, small molecule inhibitor of KCNQ2 channels. 2011 Oct 28 [updated 2013 Feb 25]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD) : National Center for Biotechnology Information (US) ; 2010–. |[2]Cheung YY, et al. Discovery of a series of 2-phenyl-N- (2- (pyrrolidin-1-yl) phenyl) acetamides as novel molecular switches that modulate modes of K (v) 7.2 (KCNQ2) channel pharmacology: identification of (S) -2-phenyl-N- (2- (pyrrolidin-1-yl) phenyl) butanamide (ML252) as a potent, brain penetrant K (v) 7.2 channel inhibitor. J Med Chem. 2012 Aug 9;55 (15) :6975-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP1; CYP2; CYP3; Voltage-gated potassium channel

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