Metallo-β-lactamase-IN-15
Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC50 values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively[1].
Product Specifications
CAS Number
1804934-57-3
UNSPSC
12352005
Target
Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/metallo-β-lactamase-in-15.html
Solubility
10 mM in DMSO
Smiles
SC[C@H]1SC[C@]2([H])SC3=CC=CC=C3N21
Molecular Formula
C10H11NS3
Molecular Weight
241.40
References & Citations
[1]Villamil, Valentina et al. “Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.” Journal of medicinal chemistry, 19 Feb. 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Metallo-β-lactamase (MBL)
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