Aceclidine
Product Specifications
UNSPSC Description
Aceclidine (Quinuclidin-3-yl acetate) is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC50: 40 μM). Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia[1][2][3].
Target Antigen
mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aceclidine.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(OC1C[N@@]2CC[C@H]1CC2)=O
Molecular Weight
169.224
References & Citations
[1]Gerald Horn, et al. Storage Stable Compositions and Methods for the Treatment of Refractive Errors of the Eye. Patent US20150290125A1.|[2]Thomas G. Gant, et al. Imidazole modulators of muscarinic acetylcholine receptor m3. Patent US20110091459A1.|[3]Cui Y, et al. Enhancement of memory function in aged mice by a novel derivative of xanomeline. Cell Res. 2008 Nov;18(11):1151-3. |[4]Hagan JJ, et al. Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics. Psychopharmacology (Berl). 1989;98(3):347-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-32067/Aceclidine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-32067/Aceclidine-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
827-61-2
Available Sizes
Curated Selection
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