THIIC

THIIC (LY2607540) is a compound with anxiolytic and antidepressant potential. It is a positive allosteric modulator of mGlu receptors, exhibits anxiolytic and antidepressant-like activities in multiple animal models, and can also affect sleep and neurochemical changes.

Product Specifications

CAS Number

[1204737-09-6]

Product Name Alternative

LY2607540

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/thiic.html

Smiles

O=C(NCC1=CC=C(C=C1)COC2=CC=C(C(O)=C2C(F)(F)F)C(C(C)C)=O)C3=CN(C=N3)C

Molecular Formula

C24H24F3N3O4

Molecular Weight

475.46

References & Citations

[1]N- (4- ((2- (trifluoromethyl) -3-hydroxy-4- (isobutyryl) phenoxy) methyl) benzyl) -1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes