A-317920
A-317920 is a selective and potent rat histamine H3 receptor (H3R) antagonist with pKi value of 9.2 and 7.0 for full-length rat and full-length human H3R, respectively. A-317920 exhibits over 130 fold selective affinity for the rat over the human H3R. A-317920 enhances cognition via H3R blockade[1].
Product Specifications
CAS Number
360551-59-3
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-317920.html
Smiles
O=C(N[C@@H](C(N1CCN(CC1)CCCOC2=CC=C(C=C2)C(C3CC3)=O)=O)C)C4=CC=CO4
Molecular Formula
C25H31N3O5
Molecular Weight
453.53
References & Citations
[1]G B Fox, et al. Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats. Inflamm Res. 2003 Apr:52 Suppl 1:S31-2. |[2]Timothy A Esbenshade, et al. Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. J Pharmacol Exp Ther. 2003 Jun;305 (3) :887-96.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
DLR-PDCD6IP-Hu-96T 96 Tests
Human Programmed Cell Death Protein 6 Interacting Protein (PDCD6IP) ELISA Kit
Sign In for Pricing
View Details 
