Beclomethasone 17-propionate

Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages[1][2][3].

Product Specifications

CAS Number

[5534-18-9]

Product Name Alternative

Beclomethasone-17-monopropionate; 17-BMP

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/beclomethasone-17-propionate.html

Purity

99.76

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](C(CO)=O)(OC(CC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C2)=O

Molecular Formula

C25H33ClO6

Molecular Weight

464.98

Precautions

H302, H315, H319, H335

References & Citations

[1]Würthwein G, et al. Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharm Drug Dispos. 1990 Jul;11 (5) :381-94.|[2]Roberts JK, et al. Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345 (2) :308-16.|[3]Plumb J, et al. Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate. PLoS One. 2013 May 21;8 (5) :e64257.