NSC 194308

NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2) . NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1].

Product Specifications

CAS Number

[90379-42-3]

UNSPSC

12352211

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc-194308.html

Purity

98.40

Solubility

DMSO : ≥ 50 mg/mL

Smiles

N=C(CS[S](=O)(O)=O)NC[C@@H]1C(CC2CC1)C2(C)C

Molecular Formula

C12H22N2O3S2

Molecular Weight

306.44

References & Citations

[1]Rakesh Chatrikhi, et al. A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex. Cell Chem Biol. 2021 Aug 19;28 (8) :1145-1157.e6.|[2]Riccardo Rozza, et al. Assessing the Binding Mode of a Splicing Modulator Stimulating Pre-mRNA Binding to the Plastic U2AF2 Splicing Factor. J Chem Inf Model. 2023 Dec 11;63 (23) :7508-7517.