8-Bromo-AMP

8-Bromo-AMP (8-Bromoadenosine 5'-monophosphate) is a membrane permeable cAMP analogue. 8-Bromo-AMP can improve the ability of the heart to recover from ischemia and reperfusion by increasing the levels of ATP, ADP, and total adenine nucleotides[1][2].

Product Specifications

CAS Number

[23567-96-6]

Product Name Alternative

8-Bromoadenosine 5'-monophosphate; 8-Bromoadenylic acid

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/8-bromo-amp.html

Purity

98.81

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C(Br)=NC3=C(N=CN=C32)N)O1)O)O)O

Molecular Formula

C10H13BrN5O7P

Molecular Weight

426.12

References & Citations

[1]Jiang J, et, al. Evidences for involvement of endogenous cAMP in Arabidopsis defense responses to Verticillium toxins. Cell Res. 2005 Aug;15 (8) :585-92.|[2]Nakai T, et, al. Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. J Cardiovasc Pharmacol. 1996 Aug;28 (2) :264-70.