KH16
KH16 is a potent and low nanomolar HDAC inhibitor. KH16 is against class I HDACs HDAC1, HDAC2, and HDAC3, with IC50 values ranging from 6 to 34 nM. KH16 induces cell apoptosis and is against tumor cells with various gene expression patterns[1].
Product Specifications
CAS Number
[3059680-59-7]
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kh16.html
Purity
98.62
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CN=C(N=C1)N2CCN(CC2)CC3=CNC4=C3C=CC=C4)NO
Molecular Formula
C18H20N6O2
Molecular Weight
352.39
References & Citations
[1]Ramy Ashry, et al. NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor. Cancers (Basel) . 2023 Jul 17;15 (14) :3650.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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